Dulce studies the development of epigenomic and transcriptomic techniques and data analysis methods for the characterisation of brain samples in healthy and disease conditions. My research focuses on Rett Syndrome (RTT), which is a severe dominant X-linked neurological disorder affecting 1:10,000 females. In -95% of the cases, RTT is caused by deleterious mutations in the Methyl-CpG-binding protein 2 (MeCP2). Development and assessment of RTT treatments have been increased since the finding that the rescue of MeCP2 function can restore RTT phenotype in mouse models. My research results suggest that neurodevelopmental damage may not be restored in symptomatic and aged individuals after MeCP2 rescue, in which supplementary treatments might need to be considered.